CURCUMIN+RESVERATROL (Double The Power In One Bottle...)

 

THE IMPACT OF CURCUMIN ON CANCER IN GENERAL AND BREAST CANCER IN PARTICULAR...

 

Where To Start!

The Endless Benefits Of Curcumin And Resveratrol...

  

  • We Use All Natural Active Patented process 3-peak Curcumin (Most potent with the highest absorption) 

  • Our liposome is Derived From Non-GMO Certified Sunflower Oil Imported From Spain. 



According to Dr. Bharat B. Aggarwal, Ph.D.: “Curcumin can selectively modulate multiple cell signaling pathways linked to inflammation and to survival, growth, invasion, angiogenesis, and metastasis of cancer cells." 

 

Liposomal Curcumin and Resveratrol created in our state-of-the-art supplement manufacturing plant. The liposomes engulf and protect the Curcumin as it is digested, making more of the active compound available in the intestines after consumption. Ultimately, the lipids help the body absorb the Curcumin and resveratrol. 

 

Water in this product exceeds USP 645 specifications required for water injection. 

 

Why Use Liposome?

According to Dr. Alec Banham: “Liposomal vitamin is packaged like a bodily cell, so it passes through the digestive barrier and delivers more than 90% of the nutrient directly to the bloodstream within minutes.”

 

Revealing The Tip Of The Iceberg Of The Endless Benefits Of Liposomal Curcmunix...

 

 

 

The Impact Of Curcumin On Breast Cancer

Abstract

Curcumin, the active ingredient of turmeric (curry spice), is believed to be associated with reducing the incidence of breast cancers in Asian countries. Anti-cancer efficacy of curcumin and analogs has been tested in pre-clinical studies in some cancer models including breast cancer. These studies reported promising results in inhibiting human cancer cell proliferation and tumorigenesis in animal models. Both in vitro and in vivo studies have shown that curcumin and its analogs target critical genes associated with angiogenesis, apoptosis, cell cycle, and metastasis. The inhibition of human breast cancer cell growth by curcumin is mediated via certain signaling cascades including the modulation of the NF-κB signaling pathway. Epidemiological and experimental data also demonstrated the efficacy of curcumin in chemoprevention and reversing chemo-resistance of tumors of certain cancers. This review summarizes the studies revealing the preventive and therapeutic effects of curcumin and its analogs with an emphasis on multi-targeted biological and molecular effects in a breast cancer model.
 

 

Curcumin as an adjuvant therapy to conventional cancer treatments

Introduction

Forty percent of Canadians develop cancer in their lifetime, and twenty-five percent of these cases are fatal (Canadian Cancer Society 2014). The standards of care for cancer are chemotherapy, radiation, and/or surgery because these modalities have demonstrated the highest treatment efficacy in clinical practice (Canadian Cancer Society 2012, Canadian Cancer Society 2015). However, patients diagnosed with chemotherapy- and radiotherapy-resistant cancers face treatment challenges (Li 2014). Thus, treatments adjuvant to conventional therapy are being explored.
 
Curcumin (diferuloylmethane) is the most thoroughly researched active component of turmeric (Chattopadhyay 2004, Lao 2006, Shishodia 2005). Research evidence demonstrates that curcumin is more effective when used in conjunction with chemotherapy than as a stand-alone therapy (Kusuhara 2012, Lin 2007). This is due to its ability to downregulate resistance proteins (Guo 2014, Rana 2015, Roy 2014) and modulate cancer stem cells, which are both integral mechanisms to cancer resistance, metastasis, and recurrence (Buhrmann 2014, Shakibaei 2014). Moreover, curcumin antagonizes many of chemotherapy’s negative side effects such as promotion of cell proliferation through NF-kB (Cabrespine-Faugeras 2010, Melisi 2007). This paper investigates the clinical potential for curcumin use with conventional therapy to improve treatment outcomes in a variety of cancers.
 

Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth.

Murali M Yallapu, Diane M Maher, Vasudha Sundram, Maria C Bell, Meena Jaggi, and Subhash C Chauhan.

 

 

 

Results

Curcumin pre-treatment considerably reduced the dose of cisplatin and radiation required to inhibit the growth of cisplatin-resistant ovarian cancer cells. During the 6 hr pre-treatment, curcumin down-regulated the expression of Bcl-XL and Mcl-1 pro-survival proteins. Curcumin pre-treatment followed by exposure to low doses of cisplatin increased apoptosis as indicated by annexin V staining and cleavage of caspase 9 and PARP. Additionally, curcumin pre-treatment lowered β-catenin expression and transcriptional activity. Nano-CUR was successfully generated and physicochemical characterization of Nano-CUR indicated an average particle size of ~70 nm, steady and prolonged release of curcumin, antibody conjugation capability and effective inhibition of ovarian cancer cell growth.

Conclusion

Curcumin pre-treatment enhances chemo/radio-sensitization in A2780CP ovarian cancer cells through multiple molecular mechanisms. Therefore, curcumin pre-treatment may effectively improve ovarian cancer therapeutics. A targeted PLGA nanoparticle formulation of curcumin is feasible and may improve the in vivotherapeutic efficacy of curcumin

 

Curcumin inhibits lung cancer cell migration and invasion through a Rac1-dependent signaling pathway.

Abstract
Curcumin, a natural and crystalline compound isolated from the plant Curcuma longa with low toxicity in normal cells, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about antimetastasis effects and mechanism of curcumin in lung cancer. Rac1 is an important small Rho GTPases family protein and has been widely implicated in cytoskeleton rearrangements and cancer cell migration, invasion, and metastasis. In this study, we examined the influence of curcumin on in vitro invasiveness of human lung cancer cells and the expressions of Rac1. The results indicate that curcumin at 10 μM slightly reduced the proliferation of 801D lung cancer cells but showed an obvious inhibitory effect on epidermal growth factor or transforming growth factor β1-induced lung cancer cell migration and invasion. Meanwhile, we demonstrated that the suppression of invasiveness correlated with inhibition of Rac1/PAK1 signaling pathways and matrix metalloproteinase (MMP) 2 and 9 protein expression by combining curcumin treatment with the methods of Rac1gene silence and overexpression in lung cancer cells. Laser confocal microscope also showed that Rac1-regulated actin cytoskeleton rearrangement may be involved in anti-invasion effect of curcumin on lung cancer cell. At last, through xenograft experiments, we confirmed the connection between Rac1 and the growth and metastasis inhibitory effect of curcumin in vivo. In summary, these data demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and MMP-9 expression, which provided a novel insight into the molecular mechanism of curcumin against lung cancer.

 

Curcumin, a natural and crystalline compound isolated from the plant Curcuma longa with low toxicity in normal cells, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about antimetastasis effects and mechanism of curcumin in lung cancer. Rac1 is an important small Rho GTPases family protein and has been widely implicated in cytoskeleton rearrangements and cancer cell migration, invasion, and metastasis. In this study, we examined the influence of curcumin on in vitro invasiveness of human lung cancer cells and the expressions of Rac1. The results indicate that curcumin at 10 μM slightly reduced the proliferation of 801D lung cancer cells but showed an obvious inhibitory effect on epidermal growth factor or transforming growth factor β1-induced lung cancer cell migration and invasion. Meanwhile, we demonstrated that the suppression of invasiveness correlated with inhibition of Rac1/PAK1 signaling pathways and matrix metalloproteinase (MMP) 2 and 9 protein expression by combining curcumin treatment with the methods of Rac1 gene silence and overexpression in lung cancer cells. Laser confocal microscope also showed that Rac1-regulated actin cytoskeleton rearrangement may be involved in anti-invasion effect of curcumin on lung cancer cell. At last, through xenograft experiments, we confirmed the connection between Rac1 and the growth and metastasis inhibitory effect of curcumin in vivo. In summary, these data demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and MMP-9 expression, which provided a novel insight into the molecular mechanism of curcumin against lung cancer.

 

Curcumin: an adjuvant therapeutic remedy for liver cancer


Shilpa SharmaAnshul TanwarDevendra K. Gupta
Abstract
The molecular signaling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied. The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery. Yet there is high associated morbidity and mortality due to advanced stages, adverse effects owing to chemotherapy and recurrence. The role of Curcumin as an adjuvant remedy is explored in this article. Curcumin stimulates apoptosis of cancer cells, acts as an anti-proliferative agent, has anti-angiogenic action, prevents tumor invasiveness and metastasis and prevents a recurrence. It also has been proven to decrease the adverse effects of chemotherapeutic agents and has a synergistic anticancer action. It acts at the molecular level and affects the various metabolic pathways involved in tumorigenesis. It also promotes healing and has anti-inflammatory, anti-oxidant and anti-infective action. This natural phytocompounds has immense anti-cancer potential and holds future promise as an adjuvant remedy to treat liver cancer.
 
 

INTRODUCING, LIPOSOMAL CURCUMINX+ RESVITAL
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