Vitamin C underappreciated for the role it plays in psychiatric health! William Wallace, Ph.D

Vitamin C underappreciated for the role it plays in psychiatric health! William Wallace, Ph.D

Ph.D. | Product Development, Scientific Affairs, and Regulatory Compliance | Dietary Supplements, Ingredients and Health Education
PMID: 1106295, 9466441, 6121305, 7225858, 28867798, 2663114

Vitamin C is underappreciated for the role it plays in psychiatric health.

There is a prima facie case for recognizing vitamin C as a contributor to psychiatric health. Research shows that the brain, relative to other organs, possesses high concentrations of vitamin C. Neurons are among the cells in the body with the highest concentrations of vitamin C. Additionally, it has been suggested that 1/3 of vitamin C in the body can be found at the sites of catecholamine (dopamine, norepinephrine, epinephrine) synthesis (e.g., the adrenals - not situated in the brain but considered “neuroendocrine tissue”). Vitamin C is needed in converting dopamine to norepinephrine by the enzyme beta-dopamine hydroxylase (vitamin C keeps copper in a reduced state so that the enzyme can use it as its primary cofactor).
Animal models demonstrate that vitamin C content in neurons is more than tenfold that of glial cells. This makes sense as heightened oxidative metabolism in neurons increases their vulnerability to oxidative stress.
Additionally, reactive oxygen species, prevalent in vitamin C-rich brain areas including the hippocampus, hypothalamus, amygdala, and cerebral cortex, play a physiological role as second messengers in synaptic plasticity mechanisms. This might highlight vitamin C's function in maintaining redox balance.
Vitamin C seems to influence glutamatergic neurotransmission, and the distribution of glutamatergic NMDA receptors is notably higher in regions with substantial vitamin C concentration, such as parts of the cortex, the amygdala, and the hippocampus.
These findings collectively suggest the potential impact of vitamin C on neuropsychiatric conditions and cognitive function.
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How vitamin C contribute to your healthy Collagen?

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