Dr. Bruce Ames
Double-strand breaks (DSBs) in DNA form as a result of exposure to exogenous agents such as radiation and certain chemicals, as well as through endogenous processes, including DNA replication and repair.
When you’re exposed to these type of radiations case DNA mutation (Double Chromosome Break) and that is very dangerous because it weaken your immune system and Cancer Cells/Zombie begin to grow including causing many other diseases.
Common micronutrient deficiencies, which are likely to damage DNA by the same mechanism as radiation and many chemicals, appear to be orders of magnitude more important (2, 10). We are currently working on comparing radiation with micronutrient deficiencies and trying to put risks in perspective. The poor are not served if huge resources are put into minor hypothetical risks and major risks are not addressed.
Sperm DNA damage and vitamins/minerals
We are investigating the effects of inadequate micronutrient intake on genetic damage to sperm (2). We have shown that folic acid deficiency decreases sperm count in rats by 90%, and that uracil is found in sperm DNA of men on low-fruit and -vegetable diets. Our recent work on folate inadequacy in humans in collaboration with the U.S. Department of Agriculture Human Nutrition laboratory (11) shows an inverse association between the level of the nonmethyl-tetrahydrofolate pool but not the methyl-tetrahydrofolate pool with both sperm count and quality, which is consistent with a uracil-misincorporation mechanism. We had previously shown (2) that men with low–vitamin C intake had more oxidative damage to their sperm DNA, and that male smokers (smoking depletes the vitamin C level markedly) had more oxidative damage to their sperm. Recent epidemiological data support the notion that smoking males have more offspring with childhood cancer.
Zinc deficiency may also contribute to sperm damage; zinc is known to be essential for normal male reproductive function. In the Middle East where low-zinc, high-phytate diets are common (phytate binds zinc so that it is nutritionally unavailable), zinc-deficient males exhibit delayed sexual maturation and hypogonadism. Zinc is present at very high concentrations in seminal fluid (∼100 μg/mL) relative to blood plasma (<1 μg/mL) and is mainly of prostatic origin. In a collaborative study between our laboratory and that of Janet King, a survey of 69 healthy men revealed suggestive correlations between seminal plasma zinc and both total sperm count and semen volume. In a recent intervention study (12), 24 subfertile men who took a daily supplement that contained both 66 mg of zinc sulfate and 5 mg of folic acid for 26 wk experienced a 74% increase (from baseline) in total normal sperm count. The study did not examine an independent effect of zinc and folate. Although vegetarian males are generally more healthy than nonvegetarians, those who consume whole grains (which contain phytate) could be at risk for low zinc intakes and possible reproductive problems in addition to the known possibility of vitamin B-12 deficiency.
The funny thing is that my Professor Dr. Bruce Ames completed this research in 1988 and i'm glad that someone like Dr. Berg recently discovered this research 🙏
The #1 Important Nutrient to Shrink Your Prostate Dr. Eric Berg (Approx. 3 minute video clip)
There are many other factors for prostate problem like, deficiency in other nutrients, unhealthy diet, obesity, eating fried/junk foods, drinking Soda's, using artificial sugar like Aspartame & Corn syrup, Smoking, Alcohol, and using specific medication including off counter pain killers & anti-acid that can cause prostate prostate health problems and cancer.
Double-strand breaks in DNA can be lethal to a cell. How do cells fix them? M. Cristina Negritto, Ph.D. (Dept. of Biology, Pomona College)
-
Each strand is composed of long sequences of the four bases, A, C, G, and T.
-
The bases on one strand of the DNA molecule pair together with complementary? bases on the opposite strand of DNA to form the ‘rungs’ of the DNA ‘ladder’.
-
The bases always pair together in the same way, A with T, C with G.
-
Each base pair is joined together by hydrogen bonds?.
-
Each strand of DNA has a beginning and an end called 5’ (five prime) and 3’ (three prime) respectively.
-
The two strands run in the opposite direction (antiparallel) to each other so that one runs 5’ to 3’ and one runs 3’ to 5’, they are called the sense strand and the antisense strand, respectively.
-
The strands are separated during DNA replication?.
-
This double helix structure was first discovered by Francis Crick and James Watson with the help of Rosalind Franklin and Maurice Wilkins.
-
The human genome is made of 3.2 billion bases of DNA but other organisms have different genome sizes.
The fact is that DNA mutation mostly caused by exposure to radiation, X-rays or Chemotherapy is true but also nutrition deficiencies is the bigger culprit!
Ref: Dr. Jacob Teitelbaum and Dr. Gottlieb’s book Real Cause Real Cure.
This state of disease due to nutritional deficiency is the basis of the propounded “triage theory” of world-class scientist Bruce Ames, Ph.D., professor of biochemistry and molecular biology at the University of California, Berkeley, and inventor of the Ames Test, the standard method used to determine whether a chemical can cause cancer.
The triage theory says that the body copes with micronutrient deficiencies by using available vitamins and minerals to ensure day-to-day survival.
The result: The body’s long-term needs are shortchanged, causing chronic diseases— specifically, the current plague of cancer, heart disease, type 2 diabetes, arthritis, osteoporosis, and Alzheimer’s.
Dr. Bruce Ames compiled the following list and it reads a lot like the label of a typical multivitamin/mineral supplement.
Acetyl-L-carnitine Alpha-lipoic acid Biotin Calcium Choline Cobalamin (vitamin B12) Copper Folate Iron Magnesium Niacin Omega-3 fatty acids Pantothenate Potassium (vitamin B6) (vitamin B2) Selenium Thiamin (vitamin B1) Vitamin D Zinc In the following sections, you’ll find a nutrient-by-nutrient guide to the level of vitamin and mineral supplementation that can prevent these deficiencies and— most important— optimize your health. For each nutrient, we also present the diseases that can be prevented, and sometimes cured, by treating a deficiency. This is one of the longest chapters in the book. Why? Because I think that nutritional deficiency is the leading cause of so many modern illnesses and that simple nutritional support is one of the most powerful weapons in your self-care arsenal.
(Professor Bruce Ames briefly explains)
Dr. David Kellen shows that Magnesium deficiencies induce mitochondria protein cross-link. There may be other mineral shortages that will cause similar things. Professor Ames continues by saying that he and Dr. Kellen plugged into Google 30 different vitamin and mineral deficiencies using key terms such as “mutation”, “cancer”, and “chromosome break” and found:
-
Calcium deficiency leads to chromosome breaks and colon cancer.
-
Folate deficiency leads to chromosome breaks in mice and humans along with colon cancer in humans.
-
Vitamin D deficiency leads to chromosome breaks and many types of cancer.
-
Magnesium deficiency leads to chromosome breaks in humans.
-
Zinc deficiency leads to Fong’s disease and esophageal cancer in humans.
-
Potassium deficiency leads to cardiovascular diseases.
-
Vitamin B12 deficiency leads to chromosome breaks.
-
Selenium deficiency leads to DNA damage and cancer in humans.
-
Omega-3 fatty acid deficiency leads to cancer.
-
Niacin deficiency leads to chromosome breaks (DNA damage).
-
Choline deficiency leads to DNA damage in humans.
Double-strand breaks (DSBs) in DNA form as a result of exposure to exogenous agents such as radiation, Xray's and certain chemicals but today's scientists showing us DNA mutation from deficiencies in specific nutrients as well as through endogenous processes.
